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Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy
| Content Provider | Scilit |
|---|---|
| Author | Chikuma, Shunsuke Kanamori, Mitsuhiro Mise-Omata, Setsuko Yoshimura, Akihiko |
| Copyright Year | 2017 |
| Description | Journal: Cancer Science Inhibition of immune checkpoint molecules, PD‐1 and CTLA4, has been shown to be a promising cancer treatment. PD‐1 and CTLA4 inhibit TCR and co‐stimulatory signals. The third T cell activation signal represents the signals from the cytokine receptors. The cytokine interferon‐γ (IFNγ) plays an important role in anti‐tumor immunity by activating cytotoxic T cells (CTLs). Most cytokines use the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, and the suppressors of cytokine signaling (SOCS) family of proteins are major negative regulators of the JAK/STAT pathway. Among SOCS proteins, CIS, SOCS1, and SOCS3 proteins can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4+ T cells and the maturation of CD8+ T cells. This review summarizes recent progress on CIS, SOCS1, and SOCS3 in terms of their anti‐tumor immunity and potential applications. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406529/pdf |
| Ending Page | 580 |
| Page Count | 7 |
| Starting Page | 574 |
| e-ISSN | 13497006 |
| DOI | 10.1111/cas.13194 |
| Journal | Cancer Science |
| Issue Number | 4 |
| Volume Number | 108 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-04-19 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Science Medical Laboratory Technology Immune Checkpoint Kinase Inhibitory Region Suppressors of Cytokine Signaling |
| Content Type | Text |
| Resource Type | Article |
