NDLI: Altered expression of key dopaminergic regulatory proteins in the postnatal brain following perinatal n-3 fatty acid dietary deficiency

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Altered expression of key dopaminergic regulatory proteins in the postnatal brain following perinatal n-3 fatty acid dietary deficiency

Content Provider	Scilit
Author	Kuperstein, Faina Eilam, Raya Yavin, Ephrain
Copyright Year	2008
Description	Journal: Journal of Neurochemistry The consequences of maternal linolenic acid (LNA, 18:3n-3) dietary deficiency on key dopamine (DA)-associated regulatory proteins in mesolimbic and mesocortical structures of the postnatal rat brain have been investigated. A marked (4.5-fold) decrease of the DA-synthesizing enzyme tyrosine hydroxylase accompanied by a down-regulation (approx 7.5-fold) of the vesicular monoamine transporter (VMAT-2) and a depletion of VMAT-associated vesicles in the hippocampus were observed in deficient offspring compared with adequately fed controls. The DA transporter (DAT) was not affected by the LNA deficiency indicative of a DAT/VMAT-2 ratio increase that may enhance the risk of damage of the dopaminergic (DAergic) terminal. A robust increase in DA receptor (DAR1 and DAR2) levels was noticed in the cortex and striatum structures possibly to compensate for the low levels of DA in synaptic clefts. Microglia activation characterized by enhanced levels of ED1 antibody and nuclear internalization of p65 NFkappaB was noticed following LNA deficiency. Diminished levels of 22:6n-3 docosahexaenoic acid (Schiefermeier and Yavin 2002), the most ubiquitous metabolite generated by LNA is proposed to reduce the anti-oxidant arsenal in the developing brain and cause microglia activation and enhanced oxidative stress to increase the risk of certain DA-associated neurological disorders.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2008.05418.x/pdf
Ending Page	671
Page Count	10
Starting Page	662
e-ISSN	14714159
DOI	10.1111/j.1471-4159.2008.05418.x
Journal	Journal of Neurochemistry
Issue Number	2
Volume Number	106
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-07-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Brain Development Docosahexaenoic Acid Maternal Nutrition Oxidative Stress Polyunsaturated Fatty Acids
Content Type	Text
Resource Type	Article

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