NDLI: N-Methyl-d-Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers

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N-Methyl-d-Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers

Content Provider	Scilit
Author	O'Malley, Stephanie S. Krishnan-Sarin, Suchitra Franco, Nicholas Cavallo, Dana A. Morean, Meghan Shi, Julia Pittman, Brian Krystal, John H.
Copyright Year	2015
Description	Journal: Alcoholism: Clinical and Experimental Research The objective of this study was to determine the effects of the N-methyl-d-aspartate (NMDA) receptor antagonist, memantine (0, 20, 40 mg/d), upon alcohol drinking and craving in heavy drinkers with or without a family history (FH) of alcoholism, and to explore the modulatory influence of the presence of impulsivity on these outcomes. Ninety-two, nontreatment-seeking, heavy drinkers received memantine or placebo for 8 days. On the eighth day, they received a priming dose of alcohol followed by a 3-hour period of alcohol access. Memantine at a dose of 20 mg reduced alcohol craving but did not influence alcohol drinking. No effects of FH were observed. In participants with higher baseline levels of impulsivity, 40 mg of memantine reduced alcohol craving but increased alcohol drinking and alcohol-induced stimulation. NMDA receptor signaling may play divergent roles in mediating alcohol cue-induced craving and alcohol drinking in heavy drinkers. The potential efficacy of memantine as monotherapy for alcohol use disorders may be limited by its tendency to disinhibit drinking in some individuals.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331214/pdf
Ending Page	307
Page Count	8
Starting Page	300
e-ISSN	15300277
DOI	10.1111/acer.12619
Journal	Alcoholism: Clinical and Experimental Research
Issue Number	2
Volume Number	39
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-02-09
Access Restriction	Open
Subject Keyword	Journal: Alcoholism: Clinical and Experimental Research Substance Abuse Family History
Content Type	Text
Resource Type	Article

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