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Helicobacter pylori -positive duodenal ulcer: three-day antibiotic eradication regimen
| Content Provider | Scilit |
|---|---|
| Author | Catalano, F. Branciforte, G. Catanzaro, R. Cipolla, R. Bentivegna, C. Brogna, A. |
| Copyright Year | 2000 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Background: The most widely used treatments for ulcer healing and Helicobacter pylori eradication consist of a 1–2 week regimen of a proton pump inhibitor plus two or three antimicrobials. Aims: To evaluate the efficacy, safety, cost, and tolerance of a three‐day regimen with three antibiotics vs. a 10‐day treatment with a proton pump inhibitor or vs. a ranitidine bismuth citrate triple therapy. Methods: Two hundred and twenty‐one patients with endoscopically‐proven H. pylori‐positive duodenal ulcers were recruited to the study. Recruited patients were assigned to one of the following four regimens: (I) omeprazole 40 mg o.m. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 10 days (OAC: 55 patients); (ii) omeprazole 40 mg o.m. on days 1–5, plus amoxycillin 1 g b.d., clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. on days 3–5 (OACM: 56 patients); (iii) ranitidine bismuth citrate 400 mg b.d. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 10 days (RAC: 54 patients); (iv) ranitidine bismuth citrate 400 mg b.d. on days 1–5, plus amoxycillin 1 g b.d., clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. on days 3–5 (RACM: 56 patients). Fisher's exact test was used to compare data regarding healing and eradication in the four groups. Results: The intention‐to‐treat eradication and ulcer healing rates for the RACM regimen were 95% and 98%, respectively. Statistically significant differences were observed, relating to the eradication and healing of ulcers, between RACM and either the RAC or OAC regimens. Conclusion: The three‐day antibiotic therapy with amoxycillin, clarithromycin and metronidazole in addition to ranitidine bismuth citrate is a very effective anti‐H. pylori regimen. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2036.2000.00839.x |
| Ending Page | 1334 |
| Page Count | 6 |
| Starting Page | 1329 |
| e-ISSN | 13652036 |
| DOI | 10.1046/j.1365-2036.2000.00839.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 10 |
| Volume Number | 14 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2000-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology |
| Content Type | Text |
| Resource Type | Article |
