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Combination of Oral Vitamin $D_{3}$with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Anand, Sanjay Rollakanti, Kishore R. Horst, Ronald L. Hasan, Tayyaba Maytin, Edward V. |
| Copyright Year | 2014 |
| Description | Journal: Photochemistry and Photobiology Photodynamic therapy (PDT), in which 5‐ALA (a precursor for protoporphyrin IX, PpIX) is administered prior to exposure to light, is a nonscarring treatment for skin cancers. However, for deep tumors, ALA‐PDT is not always effective due to inadequate production of PpIX. We previously developed and reported a combination approach in which the active form of vitamin $D_{3}$ (calcitriol) is given systemically prior to PDT to improve PpIX accumulation and to enhance PDT‐induced tumor cell death; calcitriol, however, poses a risk of hypercalcemia. Here, we tested a possible strategy to circumvent the problem of hypercalcemia by substituting natural dietary vitamin $D_{3}$ (cholecalciferol; $D_{3}$) for calcitriol. Oral $D_{3}$ supplementation (10 days of a 10‐fold elevated $D_{3}$ diet) enhanced PpIX levels 3‐ to 4‐fold, and PDT‐mediated cell death 20‐fold, in subcutaneous A431 tumors. PpIX levels and cell viability in normal tissues were not affected. Hydroxylated metabolic forms of $D_{3}$ were only modestly elevated in serum, indicating minimal hypercalcemic risk. These results show that brief oral administration of cholecalciferol can serve as a safe neoadjuvant to ALA‐PDT. We suggest a clinical study, using oral vitamin $D_{3}$ prior to PDT, should be considered to evaluate this promising new approach to treating human skin cancer. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186664/pdf |
| Ending Page | 1135 |
| Page Count | 10 |
| Starting Page | 1126 |
| e-ISSN | 17511097 |
| DOI | 10.1111/php.12286 |
| Journal | Photochemistry and Photobiology |
| Issue Number | 5 |
| Volume Number | 90 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-05-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Photochemistry and Photobiology |
| Content Type | Text |
| Resource Type | Article |
