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A Convergent Synthesis of Functionalized Alkenyl Halides through Cobalt(III)‐Catalyzed Three‐Component C−H Bond Addition
| Content Provider | Scilit |
|---|---|
| Author | Boerth, Jeffrey A. Ellman, Jonathan A. |
| Copyright Year | 2017 |
| Description | Journal: Angewandte Chemie International Edition A CoIII -catalyzed three-component coupling of C(sp2 )-H bonds, alkynes, and halogenating agents to give alkenyl halides is reported. This transformation proceeds with high regio- and diastereoselectivity, and is effective for a broad range of aryl and alkyl terminal alkynes. Diverse C-H bond partners also exhibit good reactivity for a range of heteroaryl and aryl systems as well as synthetically useful secondary and tertiary amide, urea, and pyrazole directing groups. This multicomponent transformation is also compatible with allenes in place of alkynes to furnish tetrasubstituted alkenyl halides, showcasing the first halo-arylation of allenes. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568819/pdf |
| Ending Page | 9980 |
| Page Count | 5 |
| Starting Page | 9976 |
| ISSN | 14337851 |
| e-ISSN | 15213773 |
| DOI | 10.1002/anie.201705817 |
| Journal | Angewandte Chemie International Edition |
| Issue Number | 33 |
| Volume Number | 56 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-08-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Angewandte Chemie International Edition Organic Chemistry C−h Activation Homogeneous Catalysis Multicomponent Reactions |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Catalysis |
