NDLI: The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L -homoserine lactone, inhibits porcine arterial smooth muscle contraction

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The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L -homoserine lactone, inhibits porcine arterial smooth muscle contraction

Content Provider	Scilit
Author	Lawrence, R. N. Dunn, W. R. Bycroft, B. Camara, M. Chhabra, S. R. Williams, P. Wilson, V. G.
Copyright Year	1999
Description	Journal: British Journal of Pharmacology The Pseudomonas aeruginosa quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) has been shown to suppress cytokine production in macrophages. We have examined the effect of OdDHL and related compounds on constrictor tone of porcine blood vessels. OdDHL (1-30 microM) caused a concentration-dependent inhibition of U46619-induced contractions of the coronary artery through a largely endothelium-independent mechanism, but was markedly less effective in the pulmonary artery. Quantitively similar effects to those produced by OdDHL were observed with N-(3-oxododecanoyl)-L-homocysteine thiolactone, a thiolactone derivative, while N-3-oxododecanamide, a lactone-free acyl analogue, possessed 1/3rd the potency as a vasorelaxant. Neither N-butanoyl-L-homoserine lactone nor L-homoserine lactone (up to 30 microM) were active. Our findings indicate that OdDHL inhibits vasoconstrictor tone of both pulmonary and coronary blood vessels from the pig. The vasorelaxant action of OdDHL appears to be primarily determined by the N-acyl chain length, with a minor contribution by the homoserine lactone moiety.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571710/pdf
Ending Page	848
Page Count	4
Starting Page	845
e-ISSN	14765381
DOI	10.1038/sj.bjp.0702870
Journal	British Journal of Pharmacology
Issue Number	4
Volume Number	128
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1999-10-01
Access Restriction	Open
Subject Keyword	Journal: British Journal of Pharmacology Biochemistry and Molecular Biology N-acyl Homoserine Lactone N-(3-oxododecanoyl)-l-homoserine Lactone Vascular Smooth Muscle Quorum-sensing Molecules Coronary Artery
Content Type	Text
Resource Type	Article

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The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, inhibits porcine arterial smooth muscle contraction

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