NDLI: Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy

Please wait, while we are loading the content...

Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy

Content Provider	Scilit
Author	Vasilevko, Vitaly Passos, Giselle F. Quiring, Daniel Head, Elizabeth Kim, Richard C. Fisher, Mark Cribbs, David H.
Copyright Year	2010
Description	Journal: Annals of the New York Academy of Sciences Age‐related cerebrovascular dysfunction contributes to ischemic stroke, intracerebral hemorrhages (ICHs), microbleeds, cerebral amyloid angiopathy (CAA), and cognitive decline. Importantly, there is increasing recognition that this dysfunction plays a critical secondary role in many neurodegenerative diseases, including Alzheimer's disease (AD). Atherosclerosis, hypertension, and CAA are the most common causes of blood–brain barrier (BBB) lesions. The accumulation of amyloid beta (Aβ) in the cerebrovascular system is a significant risk factor for ICH and has been linked to endothelial transport failure and blockage of perivascular drainage. Moreover, recent anti‐Aβ immunotherapy clinical trials demonstrated efficient clearance of parenchymal amyloid deposits but have been plagued by CAA‐associated adverse events. Although management of hypertension and atherosclerosis can reduce the incidence of ICH, there are currently no approved therapies for attenuating CAA. Thus, there is a critical need for new strategies that improve BBB function and limit the development of β‐amyloidosis in the cerebral vasculature.
Related Links	http://europepmc.org/articles/pmc2958685?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958685/pdf https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2010.05786.x
Ending Page	70
Page Count	13
Starting Page	58
e-ISSN	17496632
DOI	10.1111/j.1749-6632.2010.05786.x
Journal	Annals of the New York Academy of Sciences
Issue Number	1
Volume Number	1207
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-10-07
Access Restriction	Open
Subject Keyword	Journal: Annals of the New York Academy of Sciences Clinical Neurology Alzheimer's Disease Cerebral Amyloid Angiopathy Blood–brain Barrier
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Amyloid Angiopathy and Blood?Brain Barrier Changes in Alzheimer's $Disease^{b}$

Types of cerebrovascular lesions associated with severe cerebral amyloid angiopathy in Alzheimer's disease.

The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease.

Cerebral amyloid angiopathy impact on endothelium

The challenge of mixed cerebrovascular disease

Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy.

Risk Factors for Cerebral Amyloid Angiopathy in the Elderly

Pathogenic Effects of Cerebral Amyloid Angiopathy Mutations in the Amyloid β-Protein Precursor

Cerebral Amyloid Angiopathy: Accumulation of Abeta in Interstitial Fluid Drainage Pathways in Alzheimer's Disease

Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy

Similar Documents

Amyloid Angiopathy and Blood?Brain Barrier Changes in Alzheimer's $Disease^{b}$

Types of cerebrovascular lesions associated with severe cerebral amyloid angiopathy in Alzheimer's disease.

The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease.

Cerebral amyloid angiopathy impact on endothelium

The challenge of mixed cerebrovascular disease

Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy.

Risk Factors for Cerebral Amyloid Angiopathy in the Elderly

Pathogenic Effects of Cerebral Amyloid Angiopathy Mutations in the Amyloid β-Protein Precursor

Cerebral Amyloid Angiopathy: Accumulation of Abeta in Interstitial Fluid Drainage Pathways in Alzheimer's Disease

Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy