NDLI: One-week triple therapy with esomeprazole, clarithromycin and metronidazole provides effective eradication of Helicobacter pylori infection

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One-week triple therapy with esomeprazole, clarithromycin and metronidazole provides effective eradication of Helicobacter pylori infection

Content Provider	Scilit
Author	Zanten, S. Veldhuyzen Van Machado, S. Lee, J.
Copyright Year	2003
Description	Journal: Alimentary Pharmacology & Therapeutics Aim: To compare the eradication rates of treatment with esomeprazole, metronidazole and clarithromycin (EMC) vs. omeprazole, metronidazole and clarithromycin (OMC), given for 7 days. OMC treatment was followed by 3 weeks of treatment with 20 mg omeprazole alone; the EMC group received placebo. Methods: A randomized, double‐blind, controlled study was conducted in 36 Canadian centres. Patients had a minimum 3‐month history of dyspepsia, with or without a previous history of peptic ulcer disease, and were Helicobacter pylori positive by urea breath test. The eradication of H. pylori was determined by two negative breath tests performed at least 4 and 8 weeks following the completion of treatment. Results: The intention‐to‐treat and per protocol populations consisted of 379 and 339 patients, respectively. The success rates of EMC/placebo were 76% (144/190) by intention‐to‐treat and 80% (138/172) by per protocol analysis; for OMC/omeprazole, the rates were 72% (137/189) and 75% (125/167), respectively. The difference between the two treatment groups was not significant. Treatment was well tolerated. Conclusions: A 7‐day regimen of esomeprazole, metronidazole and clarithromycin is effective and well tolerated for the eradication of H. pylori infection.
Related Links	https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2036.2003.01554.x
Ending Page	1387
Page Count	7
Starting Page	1381
e-ISSN	13652036
DOI	10.1046/j.1365-2036.2003.01554.x
Journal	Alimentary Pharmacology & Therapeutics
Issue Number	11
Volume Number	17
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2003-06-02
Access Restriction	Open
Subject Keyword	Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Metronidazole and Clarithromycin
Content Type	Text
Resource Type	Article

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