NDLI: The Biosynthesis and Linkage of Teichuronic Acid to Peptidoglycan in Bacillus licheniformis

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The Biosynthesis and Linkage of Teichuronic Acid to Peptidoglycan in Bacillus licheniformis

Content Provider	Scilit
Author	Curtis, Carol A. M.
Copyright Year	1982
Description	Journal: Journal of Biological Inorganic Chemistry Membrane and wall-membrane preparations of Bacillus lichenformis 94 will, if supplied with the appropriate precursors, synthesize teichuronic acid and link it to peptidoglycan although teichuronic acid is absent from walls of this organism. B. lichenformis 94 lacks phosphoglucomutase activity and therefore cannot synthesize the precursor UDPglucuronic acid. The initial reaction of teichuronic acid biosynthesis is catalysed by a translocase and results in the formation of polyprenyl-diphospho-N-acetylgalactosaniine and the release of UMP. This reaction is not inhibited by tunicamycin. The disaccharide repeating unit of the polymer is then formed by the transfer of glucuronic acid from UDPglucuronic acid with the release of UDP. Polymerization of the repeating units occurs by incorporation of new units at the reducing terminus of the growing teichuronic acid chain and the release of polyprenyl diphosphate. The subsequent dephosphorylation of the lipid diphosphate for reuse in the biosynthetic cycle is inhibited by bacitracin. Linkage to peptidoglycan occurs by the formation of a phosphodiester bond between the reducing N-acetylgalactosamine terminus of the teichuronic acid chain and a 6-hydroxyl group of a muramic acid residue in the glycan chain of peptidoglycan. Wall-membrane preparations synthesising teichuronic acid, poly(glycero1 phosphate) teichoic acid and peptidoglycan link the teichuronic and teichoic acids to different glycan chains.
Related Links	https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1432-1033.1982.tb05857.x
Ending Page	132
Page Count	8
Starting Page	125
ISSN	09498257
e-ISSN	14321327
DOI	10.1111/j.1432-1033.1982.tb05857.x
Journal	Journal of Biological Inorganic Chemistry
Issue Number	1
Volume Number	122
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1982-02-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Biological Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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