NDLI: Antigen Presentation Pathways for Immunity to Islet Transplants: Relevance to Immunoisolation

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Antigen Presentation Pathways for Immunity to Islet Transplants: Relevance to Immunoisolation

Content Provider	Scilit
Author	Gilla, Ronald G.
Copyright Year	1999
Description	Journal: Annals of the New York Academy of Sciences Tremendous advances have been made over the past several years in the development of diverse biocompatible materials and structural designs for the implantation of immunoisolated cells and tissues. This area of bioengineering has clear application to insulin-dependent diabetes for which the implantation of micro- or macroencapsulated pancreatic islets or surrogate beta cells has great potential therapeutic benefit. This discussion concentrates on three antigen-specific immunologic processes that impede the application of islet transplantation as a therapy for insulin-dependent diabetes: (1) Allograft immunity, (2) Xenograft immunity, and (3) Autoimmune pathogenesis of Type I diabetes. Special emphasis is placed on the potential impact of these immune pathways on immunoisolated tissues.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1999.tb08508.x/pdf
Ending Page	260
Page Count	6
Starting Page	255
e-ISSN	17496632
DOI	10.1111/j.1749-6632.1999.tb08508.x
Journal	Annals of the New York Academy of Sciences
Issue Number	1
Volume Number	875
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1999-06-01
Access Restriction	Open
Subject Keyword	Journal: Annals of the New York Academy of Sciences Cell Tissue Engineering Islet Transplants
Content Type	Text
Resource Type	Article

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