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Mercaptopurine rescue after azathioprine-induced liver injury in inflammatory bowel disease
| Content Provider | Scilit |
|---|---|
| Author | Bermejo, F. LãPez-SanromãN, A. Algaba, A. Van‐Domselaar, M. Gisbert, Javier Pérez GarcãA-GarzãN, S. Garrido, E. Piqueras, B. Poza, G. De La Guerra, Ivan López‐Sanromán, A. García‐Garzón, S. |
| Copyright Year | 2010 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Azathioprine (AZA) liver toxicity arises in approximately 3% of inflammatory bowel disease patients and may result in treatment discontinuation. To describe the tolerance to mercaptopurine (MP) in patients with previous AZA-related liver injury. Retrospective description of 31 patients (14 Crohn's, 17 ulcerative colitis), in which AZA therapy was interrupted because of liver injury, with MP started as alternative therapy. Mean AZA dose was 2.2 +/- 0.4 mg x kg/day. Median (interquartile range) of AZA exposure when liver injury was detected was 2 months (1-5.2). The type of AZA-related injury was cytolitic in 32%, cholestatic in 39% and mixed in 29%. After a median of 2.5 months (0.7-5.2), the therapy was switched to MP at a mean dose of 1.3 +/- 0.2 mg x kg/day. Median of follow-up of MP therapy was 32 months (8-54). In 87.1% of patients (95%CI: 70-96%), MP was tolerated without further liver injury; of these, 77.4% tolerated full MP doses and 9.7% tolerated lower doses. In a further cohort of 12.9% of patients, (95%CI: 3-29%), liver injury reappeared (two cholestasis, two mixed), 1-3 months after the onset of MP exposure. The administration of MP is a good alternative in patients with AZA-related liver injury, before thiopurines are definitely discarded. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2009.04132.x/pdf |
| Ending Page | 124 |
| Page Count | 5 |
| Starting Page | 120 |
| e-ISSN | 13652036 |
| DOI | 10.1111/j.1365-2036.2009.04132.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 1 |
| Volume Number | 31 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Inflammatory Bowel Disease Ulcerative Colitis |
| Content Type | Text |
| Resource Type | Article |
