NDLI: Clinical relevance of terminal Schwann cells: An overlooked component of the neuromuscular junction

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Clinical relevance of terminal Schwann cells: An overlooked component of the neuromuscular junction

Content Provider	Scilit
Author	Santosa, Katherine B. Keane, Alexandra M. Jablonka-Shariff, Albina Vannucci, Bianca Snyder-Warwick, Alison K.
Copyright Year	2018
Description	Journal: Journal of Neuroscience Research The terminal Schwann cell (tSC), a type of nonmyelinating Schwann cell, is a significant yet relatively understudied component of the neuromuscular junction. In addition to reviewing the role tSCs play on formation, maintenance, and remodeling of the synapse, we review studies that implicate tSCs in neuromuscular diseases including spinal muscular atrophy, Miller-Fisher syndrome, and amyotrophic lateral sclerosis, among others. We also discuss the importance of these cells on degeneration and regeneration after nerve injury. Knowledge of tSC biology may improve our understanding of disease pathogenesis and help us identify new and innovative therapeutic strategies for the many patients who suffer from neuromuscular disorders and nerve injuries.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292684/pdf
Ending Page	1135
Page Count	11
Starting Page	1125
e-ISSN	10974547
DOI	10.1002/jnr.24231
Journal	Journal of Neuroscience Research
Issue Number	7
Volume Number	96
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2018-03-13
Access Restriction	Open
Subject Keyword	Journal: Journal of Neuroscience Research Schwann Cells Neuromuscular Junction
Content Type	Text
Resource Type	Article

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