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Improved diagnostic accuracy of breast MRI through combined apparent diffusion coefficients and dynamic contrast-enhanced kinetics
| Content Provider | Scilit |
|---|---|
| Author | Partridge, S. C. Rahbar, H. Murthy, R. Chai, X. Kurland, B. F. DeMartini, W. B. Lehman, C. D. |
| Copyright Year | 2011 |
| Description | Journal: Magnetic Resonance in Medicine This study investigated the relationship between apparent diffusion coefficient (ADC) measures and dynamic contrast-enhanced magnetic resonance imaging (MRI) kinetics in breast lesions and evaluated the relative diagnostic value of each quantitative parameter. Seventy-seven women with 100 breast lesions (27 malignant and 73 benign) underwent both dynamic contrast-enhanced MRI and diffusion weighted MRI. Dynamic contrast-enhanced MRI kinetic parameters included peak initial enhancement, predominant delayed kinetic curve type (persistent, plateau, or washout), and worst delayed kinetic curve type (washout > plateau > persistent). Associations between ADC and dynamic contrast-enhanced MRI kinetic parameters and predictions of malignancy were evaluated. Results showed that ADC was significantly associated with predominant curve type (ADC was higher for lesions exhibiting predominantly persistent enhancement compared with those exhibiting predominantly washout or plateau, P = 0.006), but was not significantly associated with peak initial enhancement or worst curve type (P > 0.05). Univariate analysis showed significant differences between benign and malignant lesions in both ADC (P < 0.001) and worst curve (P = 0.003). In multivariate analysis, worst curve type and ADC were significant independent predictors of benign versus malignant outcome and in combination produced the highest area under the receiver operating characteristic curve (0.85 and 0.78 with 5-fold cross validation). |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201817/pdf |
| Ending Page | 1767 |
| Page Count | 9 |
| Starting Page | 1759 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.22762 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 6 |
| Volume Number | 65 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2011-01-19 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Breast Cancer Diffusion-weighted Imaging (dwi) Dynamic Contrast-enhanced Mri (dce-mri) Apparent Diffusion Coefficient (adc) |
| Content Type | Text |
| Resource Type | Article |
