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Responses to Monosodium Glutamate and Guanosine 5'-Monophosphate in Rat Fungiform Taste Cellsa
| Content Provider | Scilit |
|---|---|
| Author | Lin, W. Kinnamon, S. C. |
| Copyright Year | 1998 |
| Description | Journal: Annals of the New York Academy of Sciences Monosodium glutamate (MSG) elicits a unique taste sensation called umami. The umami sensation is potentiated by the presence of 5'-ribonucleotides such as guanosine 5'-monophosphate (5'-GMP). We have used giga-seal whole cell recording to examine glutamate transduction in individual cells of isolated rat fungiform taste buds. Approximately 56% of fungiform taste cells responded to bath application of glutamate. Three types of responses occurred: decrease in inward holding current; increase in inward holding current; and a biphasic response, with an increase followed by a decrease in holding current. Similar responses were observed in response to 5'-GMP. Further, responses to 5'-GMP may occur in cells that are glutamate-insensitive, suggesting that different receptors mediate the transduction of glutamate and 5'-GMP. Simultaneous bath application of glutamate and 5'-GMP resulted in a synergistic response in some taste cells. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1998.tb10599.x/pdf |
| Ending Page | 411 |
| Page Count | 5 |
| Starting Page | 407 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.1998.tb10599.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 855 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1998-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences |
| Content Type | Text |
| Resource Type | Article |
