Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia

Content Provider	Scilit
Author	Coney, A. M. Marshall, Janice M.
Copyright Year	1998
Description	Journal: The Journal of physiology 1. In anaesthetized rats, we have examined the role of adenosine in vasodilatation evoked in the cerebral cortex by systemic hypoxia (breathing 8 % O2). Red cell flux was recorded from the surface of the exposed parietal cortex (CoRCF) by a laser Doppler probe, cortical vascular conductance (CoVC) being computed as CoRCF divided by mean arterial blood pressure. All agonists and antagonists were applied topically to the cortex. 2. Systemic hypoxia or adenosine application for 5 or 10 min, respectively, induced an increase in CoRCF and CoVC. These responses were substantially reduced by 8-phenyltheophylline (8-PT), an adenosine receptor antagonist which is non-selective between the adenosine A1 and A2A receptor subtypes. By contrast, the adenosine receptor antagonist 8-sulphophenyltheophylline (8-SPT) which is similarly non-selective, but unlike 8-PT, does not cross the blood-brain barrier, reduced the increases in CoRCF and CoVC induced by adenosine, but had no effect on those induced by hypoxia. 3. The A2A receptor agonist CGS21680 produced a substantial increase in CoRCF and CoVC, but the A1 receptor agonist 2-chloro-N6-cyclopentyladenosine had minimal effects. 4. The A2A receptor antagonist ZM241385 reduced the increase in CoRCF and CoVC induced by adenosine and reduced the increase in CoRCF induced by hypoxia. 5. We propose that exogenous adenosine that is topically applied to the cerebral cortex produces vasodilatation by acting on A2A receptors on the vascular smooth muscle. However, during systemic hypoxia, we propose that adenosine is released from endothelial cells and acts on endothelial A2A receptors to produce the major part of the hypoxia-induced dilatation in the cerebral cortex.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230973/pdf
Ending Page	518
Page Count	12
Starting Page	507
ISSN	00223751
e-ISSN	14697793
DOI	10.1111/j.1469-7793.1998.507bn.x
Journal	The Journal of physiology
Issue Number	2
Volume Number	509
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1998-06-01
Access Restriction	Open
Subject Keyword	Journal: The Journal of physiology Adenosine Receptor
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science