NDLI: Congestive heart failure and sleep apnoea-possible mechanisms and effect of CPAP therapy

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Congestive heart failure and sleep apnoea-possible mechanisms and effect of CPAP therapy

Content Provider	Scilit
Author	Greenberg, Harly E. Genovese, Joseph Huberfeld, Seymour Scharf, Steven M.
Copyright Year	1995
Description	Journal: Journal of Sleep Research Sleep-disordered breathing has been associated with increased cardiovascular morbidity and mortality. However, despite several plausible mechanisms whereby obstructive sleep apnoea might be associated with left ventricular dysfunction and congestive heart failure, only limited data exist linking those disorders. These studies are reviewed along with possible mechanisms leading to left ventricular dysfunction in obstructive sleep apnoea. Recent investigations demonstrating improvement in left ventricular function after CPAP therapy in patients with congestive heart failure are reviewed as well. Finally, new data are presented from an animal model of congestive heart failure demonstrating a beneficial effect of CPAP on cardiac index in association with a decline in systematic vascular resistance. Remarkably, these effects persisted even after CPAP was removed. Possible mechanisms whereby CPAP may lead to improvement in cardiac output are discussed.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2869.1995.tb00202.x/pdf
Ending Page	134
Page Count	5
Starting Page	130
e-ISSN	13652869
DOI	10.1111/j.1365-2869.1995.tb00202.x
Journal	Journal of Sleep Research
Volume Number	4
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1995-06-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Sleep Research Respiratory System Congestive Heart Failure Left Ventricular Dysfunction Obstructive Sleep Apnoea
Content Type	Text
Resource Type	Article

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