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Abnormal bone remodelling and increased levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) in Waldenstrom macroglobulinaemia
| Content Provider | Scilit |
|---|---|
| Author | Terpos, Evangelos Anagnostopoulos, Athanasios Kastritis, Efstathios Bamias, Aristotelis Tsionos, Konstantinos Dimopoulos, Meletios |
| Copyright Year | 2006 |
| Description | Journal: British Journal of Haematology Serum levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) and bone remodelling markers were evaluated in 38 patients with Waldenström macroglobulinaemia (WM) and correlated with clinical and laboratory variables. MIP-1alpha was elevated in WM; untreated patients had higher MIP-1alpha levels than patients in remission or with active disease after treatment. MIP-1alpha correlated with increased bone resorption, beta2-microglobulin and splenomegaly. Receptor activator of nuclear factor-kappaB ligand serum levels were elevated in WM patients; the subsequent increased bone resorption was balanced by a comparable elevation of osteoprotegerin production and bone formation. These findings may explain the absence of lytic lesions in WM patients and suggest a potential role of MIP-1alpha in WM. |
| Ending Page | 304 |
| Starting Page | 301 |
| ISSN | 2573508X |
| e-ISSN | 13652141 |
| DOI | 10.1111/j.1365-2141.2006.06017.x |
| Journal | British Journal of Haematology |
| Issue Number | 3 |
| Volume Number | 133 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: British Journal of Haematology Medical Laboratory Technology Waldenström Macroglobulinaemia Macrophage Inflammatory Protein‐1 Alpha Receptor Activator of Nuclear Factor‐κb Ligand |
| Content Type | Text |
| Resource Type | Article |
