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Ontogenetic Profile of the Adenosine Uptake Sites in Rat Forebrain
| Content Provider | Scilit |
|---|---|
| Author | Morgan, P. F. Montgomery, P. Marangos, P. J. |
| Copyright Year | 1987 |
| Description | Journal: Journal of Neurochemistry The ontogenesis of rat forebrain adenosine uptake sites labelled by [3H]nitrobenzylthioinosine ([3H]NBI) was determined and compared to that of rat forebrain adenosine receptors labelled by N6-cyclohexyl[3H]adenosine ([3H]-CHA). [3H]NBI binding is highly invariant with similar levels of [3H]NBI binding sites from embryonic day 19 to day 30 postpartum. Scatchard and Hill analyses reveal the binding of [3H]NBI in 6-day-old tissue to be indistinguishable from such binding in 30-day-old tissue. In contrast, [3H]-CHA binding is highly variant. [3H]CHA binding develops slowly but steadily from about embryonic day 19, with adult binding levels being achieved at around 25 days postpartum. The ontogenetic profile of [3H]CHA appears to coincide with synaptogenesis whereas that of [3H]NBI does not. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1987.tb00972.x/pdf |
| Ending Page | 855 |
| Page Count | 4 |
| Starting Page | 852 |
| e-ISSN | 14714159 |
| DOI | 10.1111/j.1471-4159.1987.tb00972.x |
| Journal | Journal of Neurochemistry |
| Issue Number | 3 |
| Volume Number | 49 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1987-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurochemistry [3h]nitrobenzylthioinosine N6‐cyclohexyl[3h]‐adenosine |
| Content Type | Text |
| Resource Type | Article |
