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Predictors of asthma following severe respiratory syncytial virus (RSV) bronchiolitis in early childhood
| Content Provider | Scilit |
|---|---|
| Author | Lu, Susan Hartert, Tina V. Everard, Mark L. Giezek, Hilde Nelsen, Linda Mehta, Anish Patel, Hima Knorr, Barbara Reiss, Theodore F. |
| Copyright Year | 2016 |
| Description | Journal: Pediatric Pulmonology We sought to identify predictors of asthma development following severe early childhood RSV bronchiolitis. Different definitions of asthma were also compared.This longitudinal, observational study (N = 343) followed patients (<2 years old) from a placebo-controlled trial (N = 979) of montelukast after RSV bronchiolitis to identify clinical, demographic, or biochemical predictors of asthma, atopic disorders, and chronic asthma therapy use at 6 years of age (Clinical Trials Registry Number: NCT01140048). Asthma (primary definition) was based on parental identification of wheeze at 6 AND 12 months before 6 years of age; definitions based on physician diagnosis as well as parental identification of wheeze at 6 OR 12 months (to consider seasonal effect) were also assessed. Post-hoc analyses evaluated agreement among asthma diagnosis criteria.Prevalence of asthma (primary definition by parental identification), asthma (physician diagnosis), atopic disorders, and chronic asthma therapy use (parental identification) was 6.1%, 22.4%, 36.2%, and 14.5%, respectively. Predictors for asthma (primary definition) included male gender, a relative with asthma, and RAST positive for dog dander; for physician diagnosis of asthma, high severity score for RSV bronchiolitis, high respiratory rate, and asthma diagnosis before enrollment. Predictors of atopic disorders included allergic rhinitis before enrollment, a relative with asthma, and the plasma biomarkers IL-5, IL-16, and IL-18. Predictors of chronic asthma therapy use included asthma diagnosis before enrollment and geographic region (Europe and Africa). Only 42% of patients with asthma (primary definition) also met the asthma definition by physician diagnosis and chronic asthma therapy use.Among children with early RSV bronchiolitis, hereditary factors (i.e., having a relative with asthma) and RSV bronchiolitis severity were predictors of asthma and atopic disorders at 6 years of age. Of interest, there was poor agreement among the asthma definitions evaluated. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669901/pdf |
| Ending Page | 1392 |
| Page Count | 11 |
| Starting Page | 1382 |
| e-ISSN | 10990496 |
| DOI | 10.1002/ppul.23461 |
| Journal | Pediatric Pulmonology |
| Issue Number | 12 |
| Volume Number | 51 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2016-05-06 |
| Access Restriction | Open |
| Subject Keyword | Journal: Pediatric Pulmonology Rsv Bronchiolitis Asthma Diagnosis Respiratory Syncytial Virus |
| Content Type | Text |
| Resource Type | Article |
