NDLI: Prospects for primary stroke prevention in children with sickle cell anaemia

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Prospects for primary stroke prevention in children with sickle cell anaemia

Content Provider	Scilit
Author	Casella, James F. DeBaun, Michael R.
Copyright Year	2012
Description	Journal: British Journal of Haematology This review will focus on the strengths and limitations associated with the current standard of care for primary prevention of ischaemic strokes in children with sickle cell anaemia (SCA) ‐ transcranial Doppler ultrasound (TCD) screening followed by regular blood transfusion therapy when TCD measurement is above a threshold defined by a randomized clinical trial (RCT). The theoretical basis for potential alternative strategies for primary prevention of neurological injury in SCA is also discussed. These strategies will include, but will not be limited to: immunizations to prevent bacterial infections, particularly in low income countries; management of elevated blood pressure; and targeted strategies to increase baseline haemoglobin levels with therapies such as hyroxycarbamide or potentially definitive haematopoietic stem cell transplant.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400704/pdf
Ending Page	25
Page Count	12
Starting Page	14
e-ISSN	13652141
DOI	10.1111/j.1365-2141.2011.09005.x
Journal	British Journal of Haematology
Issue Number	1
Volume Number	157
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-01-09
Access Restriction	Open
Subject Keyword	Journal: British Journal of Haematology Sickle Cell Anaemia Primary Prevention
Content Type	Text
Resource Type	Article

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