NDLI: G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function

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G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function

Content Provider	Scilit
Author	Tadevosyan, Artavazd Vaniotis, George Allen, Bruce G. Hébert, Terence E. Nattel, Stanley
Copyright Year	2012
Description	Journal: The Journal of physiology G protein-coupled receptors (GPCRs) play key physiological roles in numerous tissues, including the heart, and their dysfunction influences a wide range of cardiovascular diseases. Recently, the notion of nuclear localization and action of GPCRs has become more widely accepted. Nuclear-localized receptors may regulate distinct signalling pathways, suggesting that the biological responses mediated by GPCRs are not solely initiated at the cell surface but may result from the integration of extracellular and intracellular signalling pathways. Many of the observed nuclear effects are not prevented by classical inhibitors that exclusively target cell surface receptors, presumably because of their structures, lipophilic properties, or affinity for nuclear receptors. In this topical review, we discuss specifically how angiotensin-II, endothelin, β-adrenergic and opioid receptors located on the nuclear envelope activate signalling pathways, which convert intracrine stimuli into acute responses such as generation of second messengers and direct genomic effects, and thereby participate in the development of cardiovascular disorders.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382322/pdf
Ending Page	1330
Page Count	18
Starting Page	1313
ISSN	00223751
e-ISSN	14697793
DOI	10.1113/jphysiol.2011.222794
Journal	The Journal of physiology
Issue Number	6
Volume Number	590
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-03-14
Access Restriction	Open
Subject Keyword	Journal: The Journal of physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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