Superoxide anion-generating activity of polymorphonuclear leukocytes and monocytes in patients with lung cancer

Content Provider	Scilit
Author	Hara, Nobuyuki Ichinose, Yukifo Asoh, Hiroshi Yano, Tokujiro Kawasaki, Masayuki Ohta, Mitsuo
Copyright Year	1992
Description	Journal: Cancer Superoxide anion (O_{2}$^{−}$) production by polymorphonuclear leukocytes (PMN) and monocytes (MN) was measured in the peripheral blood of 70 patients with lung cancer. The O_{2}$^{−}$ production by these cells was decreased in many, but not all, patients. The incidence of patients with lower O_{2}$^{−}$ production increased as the stage advanced. The correlation between O_{2}$^{−}$ production by these cells and peripheral blood smears was evaluated in patients with cancer. Patients with 80% granulocytes and 40% monocytes or more in their peripheral blood had a significantly lower O_{2}$^{−}$ production by PMN and MN compared with those with less than 80% granulocytes and 40% monocytes, respectively. These results indicate that an abnormally increased number of granulocytes and monocytes in the peripheral blood of patients with cancer may depress immunoregulatory function. In addition, decreased O_{2}$^{−}$ production by these cells should be considered when assessing the defense mechanisms and susceptibility to infection of these patients.
Ending Page	1687
Starting Page	1682
ISSN	2573508X
e-ISSN	10970142
DOI	10.1002/1097-0142%2819920401%2969%3A7%3C1682%3A%3Aaid-cncr2820690707%3E3.0.co%3B2-n
Journal	Cancer
Issue Number	7
Volume Number	69
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1992-04-01
Access Restriction	Open
Subject Keyword	Polymorphonuclear Production By These Cells
Content Type	Text
Resource Type	Article