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Central Regulation of Adrenal Tyrosine Hydroxylase: Effect of Induction on Catecholamine Levels in the Adrenal Medulla and Plasma
| Content Provider | Scilit |
|---|---|
| Author | Regunathan, S. Missala, K. Sourkes, T. L. |
| Copyright Year | 1989 |
| Description | Journal: Journal of Neurochemistry The effect of induction of adrenal tyrosine hydroxylase (TH) by various centrally acting drugs on catecholamine levels in adrenal and plasma was investigated in rats. All the drugs tested, namely oxotremorine, Piribedil, B-HT 920, and HA-966, produced significant increases in adrenal dopamine content and plasma epinephrine level. Denervation of the adrenal abolished the increase in adrenal dopamine as it did the induction of tyrosine hydroxylase. The results suggest that the induced increase of adrenal TH activity, as mediated by certain drugs, results in an elevation of the plasma epinephrine level and that the adrenal dopamine content is a better indicator of the catecholamine-synthesizing capacity of the adrenal medulla than are the other catecholamines. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1989.tb09234.x/pdf |
| Ending Page | 1710 |
| Page Count | 5 |
| Starting Page | 1706 |
| e-ISSN | 14714159 |
| DOI | 10.1111/j.1471-4159.1989.tb09234.x |
| Journal | Journal of Neurochemistry |
| Issue Number | 6 |
| Volume Number | 53 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1989-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurochemistry Cell Tissue Engineering Endocrinology and Metabolism Tyrosine Hydroxylase Central Regulation |
| Content Type | Text |
| Resource Type | Article |
