NDLI: Revisiting the Natural History of IF/TA in Renal Transplantation

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Revisiting the Natural History of IF/TA in Renal Transplantation

Content Provider	Scilit
Author	Brouard, Sophie Renaudin, Karine Soulillou, Jean-Paul
Copyright Year	2011
Description	Journal: American Journal of Transplantation Despite the decrease in incidence of early clinical and subclinical rejection and increased 1-year graft survival in renal transplant patients, the rate of graft loss after the first year has been only moderately improved. Protocol biopsies obtained in the first year have shown rapid increase in the prevalence of IF/TA. This finding has been correlated with later allograft dysfunction and loss, mostly in cases of concomitant interstitial inflammation and fibrosis (1). The landmark study by Nankivell et al., performed in recipients of organs from deceased young donors under early cysclosporin-based immunosuppression, suggested two distinct phases of injury involved in IF/TA: an early tubulo-interstitial damage from ischemic injury and allograft rejection and, beyond 1 year, microvascular, glomerular and additional tubulo interstitial injury interpreted as secondary CsA toxicity (2). Since this publication, chronic antibody-mediated rejection has been better identified as leading causes of late graft dysfunction. Moreover, a recent study showed that most cases of kidney graft loss have an identifiable cause that is not idiopathic IF/TA or CNI toxicity and that alloimmunity remains the most common mechanism leading to failure (3). Thus, with the current immunosuppressive regimens and the input of molecular phenotyping, one may question the natural history of IF/TA.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2011.03456.x/pdf
Ending Page	649
Page Count	3
Starting Page	647
e-ISSN	16006143
DOI	10.1111/j.1600-6143.2011.03456.x
Journal	American Journal of Transplantation
Issue Number	4
Volume Number	11
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-03-29
Access Restriction	Open
Subject Keyword	Journal: American Journal of Transplantation Urology and Nephrology
Content Type	Text

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