NDLI: Role of the protease corin in chondrogenic differentiation of human bone marrow‐derived mesenchymal stem cells

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Role of the protease corin in chondrogenic differentiation of human bone marrow‐derived mesenchymal stem cells

Content Provider	Scilit
Author	Zhou, Haibin Zhu, Jinsong Liu, Meng Wu, Qingyu Dong, Ningzheng
Copyright Year	2017
Description	Journal: Journal of tissue engineering and regenerative medicine Mesenchymal stem cells (MSCs) have the potency to differentiate into chondrocytes, osteocytes and adipocytes. Corin is a cardiac protease that activates the natriuretic peptides, thereby regulating blood volume and pressure. In addition to the heart, corin gene upregulation was reported in bone marrow- and adipose tissue-derived MSCs that underwent osteogenic differentiation. To date, the biological significance of corin expression in MSC differentiation remains unknown. In this study we isolated and cultured human bone marrow-derived MSCs that were capable of undergoing chondrogenic, osteogenic and adipogenic lineage differentiation. By reverse transcription polymerase chain reaction (RT-PCR) and immunostaining, we found that corin expression was upregulated when these MSCs underwent chondrogenic, osteogenic and adipogenic differentiation. The upregulation of corin expression was most significant in the cells undergoing chondrogenic lineage differentiation. Silencing corin gene expression by small hairpin RNA in the MSCs inhibited chondrogenic, but not osteogenic and adipogenic, differentiation. These results suggest a novel function of corin in MSC differentiation and chondrocyte development.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547818/pdf
Ending Page	982
Page Count	10
Starting Page	973
e-ISSN	19327005
DOI	10.1002/term.2514
Journal	Journal of tissue engineering and regenerative medicine
Issue Number	4
Volume Number	12
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-11-15
Access Restriction	Open
Subject Keyword	Journal: Journal of tissue engineering and regenerative medicine Biochemistry and Molecular Biology Chondrogenic Differentiation Mesenchymal Stem Cells
Content Type	Text

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