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Zinc supplementation in prediabetes: A randomized double-blind placebo-controlled clinical trial
| Content Provider | Scilit |
|---|---|
| Author | Ranasinghe, Priyanga Wathurapatha, Wasundara S. Galappatthy, Priyadarshani Katulanda, Prasad Jayawardena, Ranil Constantine, Godwin R. |
| Copyright Year | 2018 |
| Description | Journal: Journal of diabetes To evaluate the effects of Zinc supplementation on glycaemic control, other cadio-metabolic/anthropometric parameters and progression of disease in pre-diabetes.The clinical trial was conducted as a randomized, double-blind, placebo-controlled Phase II clinical trial for a period of 12 months. The treatment group received Zinc (20mg daily). A total of 200 subjects with pre-diabetes were recruited for the study and randomly assigned into the treatment and control groups (1:1). Evaluations were done at baseline, 1, 3, 6 and 12 months. Primary outcome was defined as change in glycaemic control from baseline. A multiple regression analysis was performed, where change in outcome variables post intervention from baseline was the continuous dependant variable.Two hundred patients were recruited, 43% were males and mean age was 51.8±7.3 years. Mean serum Zinc concentration in both groups prior to the commencement of the trial was below normal. During the 12 month follow-up period a significantly higher percentage of participants in the Placebo group (25.0%) developed type-2 diabetes in comparison to the Zinc group (11.0%)(p=0.016). The FPG, OGTT, HOMA-IR, total and LDL cholesterol significantly reduced in the Zinc group, with significant improvement in β-cell function. In all four regression models the best predictor of the respective dependant variables (change in FPG, OGTT, HOMA-IR and HOMA-β) was Zinc treatment.Zinc supplementation reduced blood glucose and insulin resistance, while improving β-cell function. Furthermore, disease progression to diabetes was reduced and beneficial effects of supplementation were also noted on total and LDL cholesterol. |
| Ending Page | 397 |
| Page Count | 12 |
| Starting Page | 386 |
| e-ISSN | 17530407 |
| DOI | 10.1111/1753-0407.12621 |
| Journal | Journal of diabetes |
| Issue Number | 5 |
| Volume Number | 10 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2018-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of diabetes Zinc Supplementation Blood Glucose Insulin Resistance Pre Diabetes |
| Content Type | Text |
| Resource Type | Article |
