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Systematic review: endoscopic and imaging-based techniques in the assessment of portal haemodynamics and the risk of variceal bleeding

Content Provider	Scilit
Author	Sgouros, S. N. Vasiliadis, K. V. Pereira, S. P.
Copyright Year	2009
Description	Journal: Alimentary Pharmacology & Therapeutics Invasive measurement of the hepatic venous pressure gradient (HVPG) is regarded as the gold standard for risk stratification and the evaluation of pharmaceutical agents in patients with portal hypertension. To review the techniques for endoscopic and imaging-based assessment of portal haemodynamics, with particular emphasis on trials where the results were compared with HVPG or direct portal pressure measurement. Systematic search of the MEDLINE electronic database with keywords: portal hypertension, variceal bleeding, variceal pressure, endoscopic ultrasound, Doppler ultrasonography, magnetic resonance angiography, CT angiography, hepatic venous pressure gradient. Computed tomography angiography and endoscopic ultrasound (EUS) have been both employed for the diagnosis of complications of portal hypertension and for the evaluation of the efficacy of endoscopic therapy. Colour Doppler ultrasonography and magnetic resonance angiography has given discrepant results. Endoscopic variceal pressure measurements either alone or combined with simultaneous EUS, correlate well with HVPG and risk of variceal bleeding and have a low interobserver variability. Endoscopic and imaging-based measurements of portal haemodynamics provide an alternate means for the assessment of complications of portal hypertension. Further studies are required to validate their use in risk stratification and the evaluation of drug therapies in patients with portal hypertension.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2009.04135.x/pdf
Ending Page	976
Page Count	12
Starting Page	965
e-ISSN	13652036
DOI	10.1111/j.1365-2036.2009.04135.x
Journal	Alimentary Pharmacology & Therapeutics
Issue Number	10
Volume Number	30
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-11-01
Access Restriction	Open
Subject Keyword	Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Systematic Review Portal Hypertension Risk Stratification Patients with Portal
Content Type	Text
Resource Type	Article

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