NDLI: Genetic suppression of agrin reduces mania-like behavior in $Na^{+}$, $K^{+}$-ATPaseα3 mutant mice

Please wait, while we are loading the content...

Genetic suppression of agrin reduces mania-like behavior in $Na^{+}$, $K^{+}$-ATPaseα3 mutant mice

Content Provider	Scilit
Author	Kirshenbaum, G. S. Clapcote, S. J. Petersen, J. Vilsen, B. Ralph, M. R. Roder, J. C.
Copyright Year	2012
Description	Journal: Genes, Brain and Behavior Myshkin mice heterozygous for an inactivating mutation in the neuron-specific $Na^{+},K^{+}$-ATPase α3 isoform show behavior analogous to mania, including an abnormal endogenous circadian period. Agrin is a proteoglycan implicated as a regulator of synapses that has been proposed to inhibit activity of $Na^{+},K^{+}$-ATPase α3. We examined whether the mania-related behavior of Myshkin mice could be rescued by a reduction in the expression of agrin through genetic knockout. The suppression of agrin reduced hyperambulation and holeboard exploration, restored anxiety-like behavior (or reduced risk-taking behavior), improved prepulse inhibition and shortened the circadian period. Hence, agrin is important for regulating mania-like behavior and circadian rhythms. In Myshkin mice, the suppression of agrin increased brain $Na^{+},K^{+}$-ATPase activity by 11 ± 4%, whereas no effect on $Na^{+},K^{+}$-ATPase activity was detected when agrin was suppressed in mice without the Myshkin mutation. These results introduce agrin as a potential therapeutic target for the treatment of mania and other neurological disorders associated with reduced $Na^{+},K^{+}$-ATPase activity and neuronal hyperexcitability.
Related Links	https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1601-183X.2012.00800.x
Ending Page	443
Page Count	8
Starting Page	436
e-ISSN	1601183X
DOI	10.1111/j.1601-183x.2012.00800.x
Journal	Genes, Brain and Behavior
Issue Number	4
Volume Number	11
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-04-20
Access Restriction	Open
Subject Keyword	Journal: Genes, Brain and Behavior Behavioral Sciences
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Genetic suppression of agrin reduces mania-like behavior in $Na^{+},$ $K^{+}-ATPase$ α3 mutant mice

Attenuation of mania-like behavior in Na+,K+-ATPase α3 mutant mice by prospective therapies for bipolar disorder: Melatonin and exercise

Decreased neuronal $Na^{+},K^{+}$-ATPase activity inAtp1a3heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress

SK3 K+channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors

Gene-environment interaction influences attachment-like style in mice

Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia

Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice

Fear-related behaviors in Lurcher mutant mice exposed to a predator

The type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in mice

Genetic suppression of agrin reduces mania-like behavior in $Na^{+}$, $K^{+}$-ATPaseα3 mutant mice

Similar Documents

Genetic suppression of agrin reduces mania-like behavior in $Na^{+},$ $K^{+}-ATPase$ α3 mutant mice

Attenuation of mania-like behavior in Na+,K+-ATPase α3 mutant mice by prospective therapies for bipolar disorder: Melatonin and exercise

Decreased neuronal $Na^{+},K^{+}$-ATPase activity inAtp1a3heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress

SK3 K+channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors

Gene-environment interaction influences attachment-like style in mice

Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia

Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice

Fear-related behaviors in Lurcher mutant mice exposed to a predator

The type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in mice

Genetic suppression of agrin reduces mania-like behavior in $Na^{+}$, $K^{+}$-ATPaseα3 mutant mice