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Dynamic phosphocreatine imaging with unlocalized pH assessment of the human lower leg muscle following exercise at 3T
| Content Provider | Scilit |
|---|---|
| Author | Khegai, Oleksandr Madelin, Guillaume Brown, Ryan Parasoglou, Prodromos |
| Copyright Year | 2017 |
| Description | Journal: Magnetic Resonance in Medicine To develop a high temporal resolution imaging method that measures muscle-specific phosphocreatine (PCr) resynthesis time constant (τPCr ) and pH changes in muscles of the lower leg following exercise on a clinical 3T MRI scanner. We developed a frequency-selective 3D non-Cartesian FLORET sequence to measure PCr with 17-mm nominal isotropic resolution (28 mm actual resolution) and 6-s temporal resolution to capture dynamic metabolic muscle activity. The sequence was designed to additionally collect inorganic phosphate spectra for pH quantification, which were localized using sensitivity profiles of individual coil elements. Nineteen healthy volunteers were scanned while performing a plantar flexion exercise on an in-house developed ergometer. Data were acquired with a dual-tuned multichannel coil array that enabled phosphorus imaging and proton localization for muscle segmentation. After a 90-s plantar flexion exercise at 0.66 Hz with resistance set to 40% of the maximum voluntary contraction, τPCr was estimated at 22.9 ± 8.8 s (mean ± standard deviation) with statistical coefficient of determination r2 = 0.89 ± 0.05. The corresponding pH values after exercise were in the range of 6.9-7.1 in the gastrocnemius muscle. The developed technique allows measurement of muscle-specific PCr resynthesis kinetics and pH changes following exercise, with a temporal resolution and accuracy comparable to that of single voxel 31 P-MRS sequences. Magn Reson Med 79:974-980, 2018. © 2017 International Society for Magnetic Resonance in Medicine. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709247/pdf |
| Ending Page | 980 |
| Page Count | 7 |
| Starting Page | 974 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.26728 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 2 |
| Volume Number | 79 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-05-30 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging X-nuclei Imaging Dynamic 31p Mri Human Calf Muscle Muscle Metabolism Ph Assessment Phosphocreatine Resynthesis |
| Content Type | Text |
| Resource Type | Article |
