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Course and outcome of childhood epilepsy: A 15-year follow-up of the Dutch Study of Epilepsy in Childhood
| Content Provider | Scilit |
|---|---|
| Author | Geerts, Ada Arts, Willem F. Stroink, Hans Peeters, Els Brouwer, Oebele Peters, Boudewijn Laan, Laura Donselaar, Cees Van |
| Copyright Year | 2010 |
| Description | Journal: Epilepsia To study the course and outcome of childhood-onset epilepsy during 15-year follow-up (FU). We extended FU in 413 of 494 children with new-onset epilepsy recruited in a previously described prospective hospital-based study by questionnaire. Mean FU was 14.8 years (range 11.6-17.5 years). Five-year terminal remission (TR) was reached by 71% of the cohort. Course during FU was favorable in 50%, improving in 29%, and poor or deteriorating in 16%. Mean duration of seizure activity was 6.0 years (range 0-21.5 years), strongly depending on etiology and epilepsy type. Duration was <1 year in 25% of the cohort and exceeded 12 years in another 25%. Antiepileptic drugs (AEDs) were used by 86% during a mean of 7.4 years: one-third had their last seizure within 1 year of treatment, and one-third continued treatment at the end, although some had a 5-year TR. At last contact, 9% of the cohort was intractable. In multivariate analysis, predictors were nonidiopathic etiology, febrile seizures, no 3-month remission, and early intractability. Eighteen patients died; 17 had remote symptomatic etiology. Standardized mortality ratio for remote symptomatic etiology was 31.6 [95% confidence interval (CI) 18.4-50.6], versus 0.8 [95% CI 0.02-4.2] for idiopathic/cryptogenic etiology. In most children with newly diagnosed epilepsy, the long-term prognosis of epilepsy is favorable, and in particular, patients with idiopathic etiology will eventually reach remission. In contrast, epilepsy remains active in approximately 30% and becomes intractable in approximately 10%. AEDs probably do not influence epilepsy course; they merely suppress seizures. Mortality is significantly higher only in those with remote symptomatic etiology. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2010.02546.x/pdf |
| Ending Page | 1197 |
| Page Count | 9 |
| Starting Page | 1189 |
| e-ISSN | 15281167 |
| DOI | 10.1111/j.1528-1167.2010.02546.x |
| Journal | Epilepsia |
| Issue Number | 7 |
| Volume Number | 51 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-06-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: Epilepsia Gastroenterology and Hepatology |
| Content Type | Text |
| Resource Type | Article |
