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Meta-analysis: re-treatment of genotype I hepatitis C nonresponders and relapsers after failing interferon and ribavirin combination therapy
| Content Provider | Scilit |
|---|---|
| Author | Singal, A. G. Waljee, A. K. Shiffman, M. Bacon, B. R. Schoenfeld, P. S. |
| Copyright Year | 2010 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Aliment Pharmacol Ther 2010; 32: 969–983The efficacy of re-treating genotype I hepatitis C virus (HCV) patients who failed combination therapy with interferon/pegylated interferon (PEG-IFN) and ribavirin remains unclear.To quantify sustained virological response (SVR) rates with different re-treatment regimens through meta-analysis of randomized controlled trials (RCTs).Randomized controlled trials of genotype I HCV treatment failure patients that compared currently available re-treatment regimens were selected. Two investigators independently extracted data on patient population, methods and results. The pooled relative risk of SVR for treatment regimens was computed using a random effects model.Eighteen RCTs were included. In nonresponders to standard interferon/ribavirin, re-treatment with high-dose PEG-IFN combination therapy improved SVR compared with standard PEG-IFN combination therapy (RR = 1.49; 95% CI: 1.09–2.04), but SVR rates did not exceed 18% in most studies. In relapsers to standard interferon/ribavirin, re-treatment with high-dose PEG-IFN or prolonged CIFN improved SVR (RR = 1.57; 95% CI: 1.16–2.14) and achieved SVR rates of 43–69%.In genotype I HCV treatment failure patients who received combination therapy, re-treatment with high-dose PEG-IFN combination therapy is superior to re-treatment with standard combination therapy, although SVR rates are variable for nonresponders (≤18%) and relapsers (43–69%). Re-treatment may be appropriate for select patients, especially relapsers and individuals with bridging fibrosis or compensated cirrhosis |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2010.04427.x/pdf |
| Ending Page | 983 |
| Page Count | 15 |
| Starting Page | 969 |
| e-ISSN | 13652036 |
| DOI | 10.1111/j.1365-2036.2010.04427.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 8 |
| Volume Number | 32 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-08-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Meta Analysis |
| Content Type | Text |
| Resource Type | Article |
