NDLI: Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition

Content Provider	Scilit
Author	Yanes, Rolando E. Tarn, Derrick Hwang, Angela A. Ferris, Daniel P. Sherman, Sean P. Thomas, Courtney R. Lu, Jie Pyle, April D. Zink, Jeffrey I. Tamanoi, Fuyuhiko
Copyright Year	2012
Description	Journal: Small The exocytosis of phosphonate modified mesoporous silica nanoparticles (P‐MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P‐MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P‐MSN exocytosis enhances the drug delivery effect of CPT‐loaded P‐MSNs by improving cell killing.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767416/pdf
Ending Page	704
Page Count	8
Starting Page	697
e-ISSN	16136829
DOI	10.1002/smll.201201811
Journal	Small
Issue Number	5
Volume Number	9
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-11-14
Access Restriction	Open
Subject Keyword	Journal: Small Biomedical Engineering Mesoporous Silica Nanoparticles Lysosomal Exocytosis Drug Delivery Exocytosis Inhibition
Content Type	Text
Resource Type	Article

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Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition