The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle.

Content Provider	Scilit
Author	Allen, D. G. Kurihara, S.
Copyright Year	1982
Description	Journal: The Journal of physiology 1. The calcium-sensitive photoprotein aequorin was micro-injected into cells of rat and cat ventricular muscles. The resulting light emission is a function of intracellular free calcium concentration ([Ca2+]i). The transient increases in [Ca2+]i that accompany contraction were monitored. 2. After an increase in muscle length, the developed tension increased immediately and then showed a slow increase over a period of minutes. The peak [Ca2+]i in each contraction was initially unchanged after an increase in muscle length but then showed a slow increase with a time course similar to that of the slow tension change. 3. As a consequence of these slow changes, the shape of the tension-length relation depends on the procedure used to determine it and this change in shape can be attributed to changes in activation. 4. Immediately after an increase in muscle length the calcium transient was abbreviated. 5. When a quick release was performed during a contraction, a short-lived increase in the [Ca2+]i was observed following the release. 6. The two previous observations can both be explained if the binding constant of troponin for calcium is a function of developed tension.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1225098/pdf
Ending Page	94
Page Count	16
Starting Page	79
ISSN	00223751
e-ISSN	14697793
DOI	10.1113/jphysiol.1982.sp014221
Journal	The Journal of physiology
Issue Number	1
Volume Number	327
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1982-06-01
Access Restriction	Open
Subject Keyword	Journal: The Journal of physiology Intracellular Calcium Muscle Length Cardiac Muscle Calcium Transients Mammalian Cardiac Effects of Muscle Length On Intracellular
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science