NDLI: Hypermethylation of HOXA10 gene in mid-luteal endometrium from women with ovarian endometriomas

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Hypermethylation of HOXA10 gene in mid-luteal endometrium from women with ovarian endometriomas

Content Provider	Scilit
Author	Fambrini, Massimiliano Sorbi, Flavia Bussani, Cecilia Cioni, Riccardo Sisti, Giovanni Andersson, Karin L.
Copyright Year	2013
Description	Journal: Acta Obstetricia et Gynecologica Scandinavica A decrease in HOXA10 gene expression in eutopic mid‐secretory endometrium has been found in women with endometriosis‐associated infertility. Promoter hypermethylation of HOXA10 is thought to be the leading mechanism for epigenetic gene regulation in patients with endometriosis. In our series we documented significantly higher HOXA10 promoter methylation levels in women with ovarian endometriomas than in healthy controls during the mid‐luteal phase. Development of epigenetic‐based strategies for non‐surgical treatment of infertility related to ovarian endometriomas could be an attractive field of research in the coming years.
Ending Page	1334
Starting Page	1331
ISSN	00221295
e-ISSN	16000412
DOI	10.1111/aogs.12236
Journal	Acta Obstetricia et Gynecologica Scandinavica
Issue Number	11
Volume Number	92
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-09-11
Access Restriction	Open
Subject Keyword	Journal: Acta Obstetricia et Gynecologica Scandinavica Reproductive Biology
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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