NDLI: Sympathoexcitatory Action of a Novel Muscarinic Receptor Agonist, AF102B, and its Blockade by Pirenzepine

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Sympathoexcitatory Action of a Novel Muscarinic Receptor Agonist, AF102B, and its Blockade by Pirenzepine

Content Provider	Scilit
Author	Yoshioka, Mitsuhiro Togashi, Hiroko Matsumoto, Machiko Morii, Ken Saito, Hideya
Copyright Year	1990
Description	Journal: Basic & Clinical Pharmacology & Toxicology The pharmacological effects of a novel, selective muscarinic (M1) receptor agonist, AF102B (cis-2-methyl-spiro-(1,3-oxathiolane-5,3')-quinuclidine hydrochloride hemihydrate), on sympathetic nerve activity are described. Intravenous administration of AF102B (1 and 10 mg/kg) produced a dose-dependent increase in cardiac sympathetic nerve activity accompanied by tachycardia in spinal-intact rats. In addition, AF102B (10 mg/kg) caused a marked increase in cardiac sympathetic nerve activity and heart rate in pithed rats. Pirenzepine (50 micrograms/kg) inhibited these sympathoexcitatory effects of AF102B (10 mg/kg) in pithed rats. These findings suggest that AF102B possesses a sympathoexcitatory action which is mediated by M1-receptors.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0773.1990.tb00788.x/pdf
Ending Page	87
Page Count	4
Starting Page	84
e-ISSN	17427843
DOI	10.1111/j.1600-0773.1990.tb00788.x
Journal	Basic & Clinical Pharmacology & Toxicology
Issue Number	1
Volume Number	67
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1990-07-01
Access Restriction	Open
Subject Keyword	Journal: Basic & Clinical Pharmacology & Toxicology Cardiac Sympathetic Sympathoexcitatory Action
Content Type	Text
Resource Type	Article

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