NDLI: Interventions for preventing reactions to snake antivenom

Please wait, while we are loading the content...

Interventions for preventing reactions to snake antivenom

Content Provider	Scilit
Author	Nuchprayoon, Issarang Garner, Paul
Copyright Year	1999
Description	Journal: Cochrane Database of Systematic Reviews Antivenom is used to neutralise snake bite toxins in people showing evidence of envenomation. It is made from animal sera, and adverse effects, including life threatening anaphylaxis, are common. To assess the effects of drugs given routinely with snake antivenom to prevent adverse effects. Cochrane controlled trials register; contact with researchers in the field. Randomised and quasi-randomised trials testing routine adrenaline (epinephrine), antihistamines, or corticosteroids. The two authors applied the inclusion criteria, assessed trial quality, and extracted the data. We sought additional data from trialists where required. One trial in Sri Lanka (n = 105) giving adrenaline with polyspecific antivenom showed fewer adverse reactions in the adrenaline group, and this effect was preserved when stratified for severity. One trial in Brazil (n = 101) using three types of Bothrops antivenom showed no benefit of antihistamine drugs. Routine prophylactic adrenaline for polyvalent antivenom known to have high adverse event rates seems sensible, based on this one trial. If clinicians believe local factors do not justify routine adrenaline, then they should test their belief in a randomised trial. Antihistamine appears to be of no obvious benefit in preventing acute reactions from antivenoms.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017854/pdf http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002153/pdf
ISSN	1469493X
e-ISSN	14651858
DOI	10.1002/14651858.cd002153
Journal	Cochrane Database of Systematic Reviews
Issue Number	2
Volume Number	1999
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1999-10-25
Access Restriction	Open
Subject Keyword	Journal: Cochrane Database of Systematic Reviews Obstetrics and Gynecology
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in