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Human IgM Monoclonal Antibody to Ganglioside GM2 and Complement Suppress Virus Propagation inEx VivoCultures of Lymphocytes from HIV-1 Infected Patients
| Content Provider | Scilit |
|---|---|
| Author | Okada, Noriko Wu, Xiaoshan Mizokami, Masashi Irie, Reiko F. Okada, Hidechika |
| Copyright Year | 1999 |
| Description | Journal: Microbiology and Immunology HIV‐1 infection induces aberrant ganglioside GM2 expression on infected cell lines, and human IgM anti‐GM2 monoclonal antibody (L55 Ab) together with normal fresh human serum (FHS) as a source of complement causes complement mediated cytolysis of HIV‐1 infected cells as well as HIV‐1 particles. We report here that high expression of GM2 was also detected on HIV‐1 infected lymphocytes from HIV‐1 seropositive patients. L55 Ab effectively suppressed the generation of HIV in the presence of FHS in primarily cultured lymphocytes from HIV‐1 infected patients in ex vivo experiments, and the suppression was enhanced additively by AZT. These data suggest that L55 Ab may increase the therapeutic effect of chemotherapy. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1348-0421.1999.tb02462.x |
| Ending Page | 727 |
| Page Count | 5 |
| Starting Page | 723 |
| ISSN | 03855600 |
| e-ISSN | 13480421 |
| DOI | 10.1111/j.1348-0421.1999.tb02462.x |
| Journal | Microbiology and Immunology |
| Issue Number | 7 |
| Volume Number | 43 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1999-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Microbiology and Immunology Ex Vivo |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology |
