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Fate of the Mate: The Influence of Delayed Graft Function in Renal Transplantation on the Mate Recipient
| Content Provider | Scilit |
|---|---|
| Author | Johnson, J. F. Jevnikar, A. M. Mahon, J. L. Muirhead, N. |
| Copyright Year | 2009 |
| Description | Journal: American Journal of Transplantation Delayed graft function (DGF) in a deceased-donor renal recipient is associated with allograft dysfunction 1-year posttransplant. There is limited research about the influence to allograft function on the mate of a DGF recipient over time. Using a retrospective cohort design, we studied 55 recipients from a single center. The primary outcome was the change in glomerular filtration rate (GFR) 1-year posttransplant. The secondary outcome was the GFR at baseline. We found that mates to DGF recipients had a mean change in GFR 1-year posttransplant of -11.2 mL/min, while the control group had a mean change of -0.4 mL/min. The difference in the primary outcome was significant (p = 0.025) in a multivariate analysis, adjusting for cold ischemic time, panel reactive antibody level, allograft loss, human leukocyte antibody (HLA)-B mismatches and HLA-DR mismatches. No significant difference between groups was found in baseline GFR. In conclusion, mates to DGF recipients had a significantly larger decline in allograft function 1-year posttransplant compared to controls with similar renal function at baseline. We believe strategies that may preserve allograft function in these'at-risk'recipients should be developed and tested. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2009.02692.x/pdf |
| Ending Page | 1801 |
| Page Count | 6 |
| Starting Page | 1796 |
| e-ISSN | 16006143 |
| DOI | 10.1111/j.1600-6143.2009.02692.x |
| Journal | American Journal of Transplantation |
| Issue Number | 8 |
| Volume Number | 9 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: American Journal of Transplantation Deceased‐donor Kidneys Delayed Graft Function (dgf) Glomerular Filtration Rate Multivariate Analysis |
| Content Type | Text |
| Resource Type | Article |
