NDLI: Control of Vicinal Stereocenters through Nickel-Catalyzed Alkyl-Alkyl Cross-Coupling

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Control of Vicinal Stereocenters through Nickel-Catalyzed Alkyl-Alkyl Cross-Coupling

Content Provider	Scilit
Author	Mu, Xin Shibata, Yu Makida, Yusuke Fu, Gregory C.
Copyright Year	2017
Description	Journal: Angewandte Chemie International Edition Vicinal stereocenters are found in many natural and unnatural compounds. Although metal-catalyzed cross-coupling reactions of unactivated alkyl electrophiles are emerging as a powerful tool in organic synthesis, there have been virtually no reports of processes that generate, much less control, vicinal stereocenters. In this investigation, we establish that a chiral nickel catalyst can mediate doubly stereoconvergent alkyl-alkyl cross-coupling, specifically, reactions of a racemic pyrrolidine-derived nucleophile with cyclic alkyl halides (as mixtures of stereoisomers) to produce vicinal stereocenters with very good stereoselectivity.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595219/pdf
Ending Page	5824
Page Count	4
Starting Page	5821
ISSN	14337851
e-ISSN	15213773
DOI	10.1002/anie.201702402
Journal	Angewandte Chemie International Edition
Issue Number	21
Volume Number	56
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-04-19
Access Restriction	Open
Subject Keyword	Journal: Angewandte Chemie International Edition Organic Chemistry Asymmetric Synthesis
Content Type	Text
Resource Type	Article
Subject	Chemistry Catalysis

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