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4D-CT motion estimation using deformable image registration and 5D respiratory motion modeling
| Content Provider | Scilit |
|---|---|
| Author | Yang, Deshan Lu, Wei Low, Daniel A. Deasy, Joseph O. Hope, Andrew J. Naqa, Issam El |
| Copyright Year | 2008 |
| Description | Journal: Medical Physics Four-dimensional computed tomography (4D-CT) imaging technology has been developed for radiation therapy to provide tumor and organ images at the different breathing phases. In this work, a procedure is proposed for estimating and modeling the respiratory motion field from acquired 4D-CT imaging data and predicting tissue motion at the different breathing phases. The 4D-CT image data consist of series of multislice CT volume segments acquired in ciné mode. A modified optical flow deformable image registration algorithm is used to compute the image motion from the CT segments to a common full volume 3D-CT reference. This reference volume is reconstructed using the acquired 4D-CT data at the end-of-exhalation phase. The segments are optimally aligned to the reference volume according to a proposed a priori alignment procedure. The registration is applied using a multigrid approach and a feature-preserving image downsampling maxfilter to achieve better computational speed and higher registration accuracy. The registration accuracy is about 1.1 +/- 0.8 mm for the lung region according to our verification using manually selected landmarks and artificially deformed CT volumes. The estimated motion fields are fitted to two 5D (spatial 3D+tidal volume+airflow rate) motion models: forward model and inverse model. The forward model predicts tissue movements and the inverse model predicts CT density changes as a function of tidal volume and airflow rate. A leave-one-out procedure is used to validate these motion models. The estimated modeling prediction errors are about 0.3 mm for the forward model and 0.4 mm for the inverse model. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673589/pdf |
| Ending Page | 4590 |
| Page Count | 14 |
| Starting Page | 4577 |
| e-ISSN | 24734209 |
| DOI | 10.1118/1.2977828 |
| Journal | Medical Physics |
| Issue Number | 10 |
| Volume Number | 35 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-09-19 |
| Access Restriction | Open |
| Subject Keyword | Journal: Medical Physics Radiology, Nuclear Medicine and Imaging Computer Simulation Artificial Intelligence Motion Estimation |
| Content Type | Text |
| Resource Type | Article |
