NDLI: Diamminetetrakis(carboxylato)platinum(IV) Complexes – Synthesis, Characterization, and Cytotoxicity

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Diamminetetrakis(carboxylato)platinum(IV) Complexes – Synthesis, Characterization, and Cytotoxicity

Content Provider	Scilit
Author	Hoffmeister, Björn R. Adib‐Razavi, Mahsa S. Jakupec, Michael A. Galanski, Markus Keppler, Bernhard K.
Copyright Year	2012
Description	Journal: Chemistry & Biodiversity A series of eight novel diamminetetrakis(carboxylato)platinum(IV) complexes was synthesized and characterized by multinuclear$ ^{1}$H‐,$ ^{13}$C‐,$ ^{15}$N‐, and$ ^{195}$Pt‐NMR spectroscopy. Their antiproliferative potency was evaluated in three human cancer cell lines representing ovarian (CH1), lung (A549), and colon carcinoma (SW480). In cisplatin‐sensitive CH1 cancer cells, cytotoxicity was found in the low micromolar range, whereas, in inherently cisplatin‐resistant A549 and SW480 cells, the activity was very low or negligible. Astonishingly, raise in lipophilicity of the complexes, as found in the case of cisplatin analogs, did not result in a significant enhancement of the cytotoxic effect.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499686/pdf
Ending Page	1848
Page Count	9
Starting Page	1840
e-ISSN	16121880
DOI	10.1002/cbdv.201200019
Journal	Chemistry & Biodiversity
Issue Number	9
Volume Number	9
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-09-13
Access Restriction	Open
Subject Keyword	Journal: Chemistry & Biodiversity Medicinal Chemistry Platinum Complexes Diamminetetrakis(carboxylato) Complexes Antiproliferative Activity
Content Type	Text
Resource Type	Article

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