NDLI: Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK / mTOR signaling pathway

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Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK / mTOR signaling pathway

Content Provider	Scilit
Author	Zhang, Yujiao Fan, Yizeng Huang, Shangke Wang, Guanying Han, Rui Lei, Fuxi Luo, Anqi Jing, Xin Zhao, Lin Gu, Shanzhi Zhao, Xinhan
Copyright Year	2018
Description	Journal: Cancer Science Thymoquinone (TQ, 2‐methyl‐5‐isopropyl‐1,4‐benzoquinone), a bioactive constituent extracted from the seeds of Nigella sativa, has been proved to exert anti‐tumor efficiency in various cancers. Autophagy is a self‐digestion phenomenon and its role in tumor formation and progression remains to be controversial. In the present study, we investigated the effects of TQ on RCC cell lines (786‐O and ACHN) using wound healing assay, Transwell assay and western blot. Then we found TQ effectively inhibited metastatic capacities of RCC cells in vitro, which was also verified in xenograft model. Meanwhile, we observed LC3 puncta and detected the expression of LC3 in TQ‐treated RCC cells, and then found autophagy was induced by TQ in 786‐O and ACHN cell lines. In addition, TQ inhibited the migration, invasion and reserved the EMT in RCC cells in an autophagy‐dependent manner. To further explore the underlying mechanism, we detected the AMPK/mTOR signaling pathway. The results indicated that TQ inhibited the metastasis of RCC cells by inducing autophagy via AMPK/mTOR signaling pathway. In conclusion, our findings provide a novel therapeutic strategy which aims at TQ‐induced autophagy in RCC treatment. This article is protected by copyright. All rights reserved.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272120/pdf
Ending Page	3873
Page Count	9
Starting Page	3865
e-ISSN	13497006
DOI	10.1111/cas.13808
Journal	Cancer Science
Issue Number	12
Volume Number	109
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2018-09-27
Access Restriction	Open
Subject Keyword	Journal: Cancer Science Biomedical Engineering
Content Type	Text
Resource Type	Article

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