NDLI: Evaluation of stratus®CS Stat fluorimetric analyser for measurement of cardiac markers Troponin I (cTnI), creatine kinase MB (CK-MB), and myoglobin

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Evaluation of stratus®CS Stat fluorimetric analyser for measurement of cardiac markers Troponin I (cTnI), creatine kinase MB (CK-MB), and myoglobin

Content Provider	Scilit
Author	Bénéteau-Burnat, Bénédicte Baudin, Bruno Vaubourdolle, Michel
Copyright Year	2001
Description	Journal: Journal of Clinical Laboratory Analysis Myoglobin, CK-MB, and Troponin I (cTnI) are cardiac muscle necrosis markers that are useful for detecting acute myocardial infarction (AMI). The Stratus CS (Dade Behring, Inc.) is a discrete fluorimetric immunoassay analyser designed for the determination of the three cardiac markers from a single sample of whole blood or plasma. Overall analytical performances of the Stratus CS provided by Dade Behring were evaluated according to the French Society of Clinical Biology guidelines. Within-run imprecision (n = 20) for the three parameters at three levels gave values under 5%, whereas CVs for between-run imprecision (n = 20) were under 6%. The sensitivities were 0.03 microg/L for cTnI and 0.4 microg/L for CK-MB. Linearities extended from 0-50 microg/L for cTnI, 0-140 microg/L for CK-MB, and 1-900 microg/L for myoglobin. The results, particularly those obtained on whole-blood samples, correlated well with those obtained on Stratus II. We did not find any interference with haemolysis, icterus, or lipemia. The system was very easy to use, and fulfills the requirements for the analysis of the three cardiac markers in patients with acute chest pain in emergency situations.
Ending Page	318
Starting Page	314
ISSN	00221295
e-ISSN	10982825
DOI	10.1002/jcla.1043
Journal	Journal of Clinical Laboratory Analysis
Issue Number	6
Volume Number	15
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2001-11-06
Access Restriction	Open
Subject Keyword	Journal: Journal of Clinical Laboratory Analysis Medical Laboratory Technology Creatine Kinase Troponin I
Content Type	Text
Resource Type	Article
Subject	Physiology

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