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Lack of Association between a GABAB Receptor 1 Gene Polymorphism and Temporal Lobe Epilepsy
| Content Provider | Scilit |
|---|---|
| Author | Stögmann, Elisabeth Zimprich, Alexander Baumgartner, Christoph Gleiss, Andreas Zimprich, Fritz |
| Copyright Year | 2006 |
| Description | Journal: Epilepsia Recently a coding nonsynonymous single-nucleotide polymorphism (SNP; G1465A) in the GABBR1 gene was reported to be associated with the incidence and severity of temporal lobe epilepsy (TLE). To clarify the role of this polymorphism in TLE, we attempted to replicate this study.We genotyped 188 unrelated patients with TLE (110 women, 78 men) and 259 controls of middle European descent by a restriction-length polymerase chain reaction (PCR) assay.Only two (0.5%) patients and none of the controls exhibited the heterozygous A/G genotype, which was previously reported to be overrepresented among patients as compared with controls.Although our study was sufficiently powered, we could not replicate the original association. Potential reasons for this failure could lie in subtle genetic differences between the studied populations or differences in the TLE phenotypes. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2006.00441.x/pdf |
| Ending Page | 439 |
| Page Count | 3 |
| Starting Page | 437 |
| e-ISSN | 15281167 |
| DOI | 10.1111/j.1528-1167.2006.00441.x |
| Journal | Epilepsia |
| Issue Number | 2 |
| Volume Number | 47 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Epilepsia Clinical Neurology Temporal Lobe Epilepsy Gene Polymorphism Association Study |
| Content Type | Text |
| Resource Type | Article |
