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Mechanism of resistance ofBacillus subtilisspores to chlorhexidine
| Content Provider | Scilit |
|---|---|
| Author | Shaker, L. A. Furr, J. R. Russell, A. D. |
| Copyright Year | 1988 |
| Description | Journal: Journal of Applied Bacteriology Chlorhexidine diacetate (CHA) was rather more sporicidal at 20 degrees C to urea-dithreitol-sodium lauryl sulphate (UDS)-treated spores of Bacillus subtilis NCTC 8236 than to urea-dithiothreitol (UDT)-treated or normal (untreated) spores. UDS spores adsorbed more CHA from solution than did the other two forms. No differences in hydrophobicity, as determined by hydrophobic interaction chromatography (HIC) or bacterial adherence to hydrocarbon (BATH), could be detected between the three spore types. Germinating spores took up much less CHA than did outgrowing spores. Germinating cells were considerably more hydrophobic, as measured by the BATH technique, than outgrowing cells or normal spores. Chlorhexidine diacetate increased the apparent hydrophobicity of the two latter forms, but this effect could be partially reversed by subsequent exposure to a non-ionic surfactant. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2672.1988.tb02444.x/pdf |
| Ending Page | 539 |
| Page Count | 9 |
| Starting Page | 531 |
| ISSN | 00218847 |
| DOI | 10.1111/j.1365-2672.1988.tb02444.x |
| Journal | Journal of Applied Bacteriology |
| Issue Number | 6 |
| Volume Number | 64 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1988-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Applied Bacteriology Pharmacology and Pharmacy Chlorhexidine Diacetate |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology Applied Microbiology and Biotechnology |