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Linking αMSH with PPARγ in B16-F10 melanoma
| Content Provider | Scilit |
|---|---|
| Author | Maresca, Vittoria Flori, Enrica Camera, Emanuela Bellei, Barbara Aspite, Nicaela Ludovici, Matteo Catricalà, Caterina Cardinali, Giorgia Picardo, Mauro |
| Copyright Year | 2012 |
| Description | Journal: Pigment Cell & Melanoma Research We have discovered a new α‐melanocyte stimulating hormone (α‐MSH)/peroxisome proliferator activated receptor‐γ (PPAR‐γ) connection in B16‐F10 cells. Both PPAR‐γ up‐regulation and its induction as an active transcription factor were observed in response to α‐MSH. The α‐MSH/PPAR‐γ connection influenced both pigmentation and proliferation. The forskolin‐stimulated cAMP/PKA pathway was not able to induce either PPAR‐γ translocation into the nucleus or PPAR‐γ transcriptional activity. As the melanocortin‐1 receptor, the specific receptor for the α‐MSH, is a G‐protein coupled receptor, we wondered whether the phosphatidylinositol $[PI(4,5)P_{2}/PLC_{β}$] signal pathway was involved in mediating the α‐MSH‐dependent PPAR‐γ activation. Employing inhibitors of $PI(4,5)P_{2}/PLC_{β}$ pathway, the results of our experiments suggested that this pathway was promoted by α‐MSH and that α‐MSH played a role in mediating PPAR‐γ activation. We have demonstrated, for the first time, that α‐MSH induces the $PI(4,5)P_{2}/PLC_{β}$ pathway, through analysis of the basic steps of the pathway. The α‐MSH effect on PPAR‐γ was independent of animal species and was not correlated with the physio‐pathological status. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1755-148X.2012.01042.x |
| Ending Page | 127 |
| Page Count | 15 |
| Starting Page | 113 |
| e-ISSN | 1755148X |
| DOI | 10.1111/j.1755-148x.2012.01042.x |
| Journal | Pigment Cell & Melanoma Research |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-08-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Pigment Cell & Melanoma Research Α‐melanocyte Stimulating Hormone Peroxisome Proliferator Activated Receptor‐γ |
| Content Type | Text |
| Resource Type | Article |
