Loading...
Please wait, while we are loading the content...
Similar Documents
High Maternal Levels of Hemoglobin A1cAssociated with Delayed Fetal Lung Maturation in Insulin-Dependent Diabetic Pregnancies
| Content Provider | Scilit |
|---|---|
| Author | Ylinen, Kari |
| Copyright Year | 1987 |
| Description | Journal: Acta Obstetricia et Gynecologica Scandinavica Phosphatidylglycerol (PG) in 227 amniotic fluid specimens obtained by amniocentesis during the third trimester and hemoglobin $A_{1C}$ (Hb $A_{1C}$) in 889 maternal blood specimens obtained between 6 and 39 gestational weeks were measured for 115 singleton insulin-dependent diabetic pregnancies without major fetal malformations or stillbirths. The fetuses of diabetics whose mean Hb $A_{1C}$ during pregnancy was 8.5% or more remained PG-negative more often than those in the pregnancies with the mean Hb $A_{1C}$ below 8.5% at 37 (4/7 vs. 8/68, $x^{2}$ = 10.2, p<0.01) and 38 (2/7 vs. 2/84, $x^{2}$ = 5.2, p <0.05) completed weeks of gestation. The fetuses of the patients with a mean Hb $A_{1C}$ 8.0% or more were more often PG-negative at 37 gestational weeks (7/15) than those in the pregnancies with a mean Hb $A_{1C}$below 8.0% (5/60, $x^{2}$ = 10.4, p <0.005). Because Hb $A_{1C}$ reflects long-term blood glucose levels, the results suggest that maternal hyperglycemia, or other metabolic disturbances associated with hyperglycemia, is the cause of delayed fetal lung maturation among insulin-dependent diabetics. |
| Ending Page | 266 |
| Starting Page | 263 |
| ISSN | 00221295 |
| e-ISSN | 16000412 |
| DOI | 10.3109/00016348709020759 |
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Issue Number | 3 |
| Volume Number | 66 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1987-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Obstetricia et Gynecologica Scandinavica Endocrinology and Metabolism Gestational Weeks Insulin Dependent Dependent Diabetic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
