NDLI: Leishmanial Amastigote Antigen P-2 Induces Major Histocompatibility Complex Class II-Dependent Natural Killer-Cell Reactivity in Cells from Healthy Donors

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Leishmanial Amastigote Antigen P-2 Induces Major Histocompatibility Complex Class II-Dependent Natural Killer-Cell Reactivity in Cells from Healthy Donors

Content Provider	Scilit
Author	Nylén, Susanne Maasho, K. Mahon-Pratt, D. Mc Akuffo, H.
Copyright Year	2004
Description	Journal: Scandinavian journal of immunology Innate mechanisms involving natural killer cells have been implied to play an important role in immunity against Leishmania infection. Previous studies have evaluated responses to three purified amastigote antigens, P-2, P-4 and P-8, of Leishmania pifanoi. The P-4 and P-8 antigens have been demonstrated to induce protection in mouse models, as well as to induce cellular responses in American cutaneous leishmaniasis patients. Cells from Leishmania aethiopica-infected leishmaniasis patients preferentially responded to P-8 and, to a lesser extent, to the cysteine proteinase, P-2. In this study, it is shown that cells from healthy donors, including cells from truly naïve donors (cord blood), could be stimulated to proliferation and cytokine production by P-2. The main proliferating cell types in healthy adult donors were CD16/56(+) and the CD8(+) cells. Blocking of major histocompatibility complex (MHC) class II with alpha-MHC class II antibodies markedly inhibited proliferation and interferon-gamma (IFN-gamma) production, whereas interleukin-10 production was not affected. Experimental evidence indicates that CD4(+) cells were not necessary for the proliferative and IFN-gamma responses; however, an adherent cell population was required. Furthermore, CD16/56(+) cells expressing MHC class II were expanded following P-2 stimulation. The responses to P-2 show a striking similarity to responses induced by the vaccine candidate Leishmania homologue of receptors for activated C-kinase (LACK) in healthy donors. The responses described here may not be desirable when aiming at inducing protective immune responses with a vaccine, and the implications of these results for the development of vaccines against leishmaniasis are discussed.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.0300-9475.2004.01388.x/pdf
Ending Page	304
Page Count	11
Starting Page	294
ISSN	03009475
e-ISSN	13653083
DOI	10.1111/j.0300-9475.2004.01388.x
Journal	Scandinavian journal of immunology
Issue Number	3
Volume Number	59
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2004-03-01
Access Restriction	Open
Subject Keyword	Journal: Scandinavian journal of immunology Tropical Medicine Natural Killer Cells
Content Type	Text
Resource Type	Article
Subject	Medicine Immunology

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