NDLI: Cloning and sequencing of the gene coding for aspartate aminotransferase from the thermoacidophilic archaebacterium Sulfolobus solfataricus

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Cloning and sequencing of the gene coding for aspartate aminotransferase from the thermoacidophilic archaebacterium Sulfolobus solfataricus

Content Provider	Scilit
Author	Cubellis, Maria Vittoria Rozzo, Carla Nitti, Gianpaolo Arnone, Maria Immacolata Marino, Gennaro Sannia, Giovanni
Copyright Year	1989
Description	Journal: Journal of Biological Inorganic Chemistry The gene coding for aspartate aminotransferase (EC 2.6.1.1) has been cloned from the extreme thermoacidophilic archaebacterium Sulfolobus solfataricus strain MT4. Partial sequence data obtained directly from the purified protein and from the two cyanogen-bromide-generated peptides confirm the primary structure of aspartate aminotransferase inferred from the nucleotide sequence of its gene. A comparison of the enzyme with other aminotransferases revealed an interesting similarity with tyrosine aminotransferase from rat liver (EC 2.6.1.5) and allowed some tentative assignments of the residues implied in the catalysis. The aspartate aminotransferase gene-flanking regions were compared to those of other archaebacterial genes already described in the literature with the aim of identifying potential regulatory sites.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1989.tb15219.x/pdf
Ending Page	381
Page Count	7
Starting Page	375
ISSN	09498257
e-ISSN	14321327
DOI	10.1111/j.1432-1033.1989.tb15219.x
Journal	Journal of Biological Inorganic Chemistry
Issue Number	1-2
Volume Number	186
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1989-12-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Biological Inorganic Chemistry Biotechnology and Microbiology Aspartate Aminotransferase Thermoacidophilic
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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